Nicolosamide Bolus 1250 mg
Niclosamide Bolus imalepheretsa phosphorylation mu mitochondria ya cestodes.Onse mu vitro ndi mu vivo, zigawo za scolex ndi proximal zimaphedwa pokhudzana ndi mankhwalawa.The anamasulidwa scolex akhoza kugayidwa m'matumbo;Choncho, zingakhale zosatheka kuzindikira scolex mu ndowe.Niclosamide Bolus ndi taenicidal ikugwira ntchito ndipo imachotsa osati zigawo zokha komanso scolex.
Ntchito ya Niclosamide Bolus motsutsana ndi mphutsi ikuwoneka chifukwa cha kulepheretsa kwa mitochondrial oxidative phosphorylation;Kupanga kwa anaerobic ATP kumakhudzidwanso.
Ntchito ya cestocidal ya Niclosamide Bolus imachitika chifukwa cholepheretsa kuyamwa kwa shuga ndi tepiworm komanso kulumikiza kwa oxidative phosphorylation mu mitochondria ya cestodes.Kuchuluka kwa lactic acid chifukwa cha kutsekeka kwa Krebs kupha mphutsi.
Zizindikiro
Niclosamide Bolus imasonyezedwa m’ziŵeto, Nkhuku, Agalu ndi Amphaka komanso mu Immature paramphistomiasis (Amphistomiasis) ya Ng’ombe, Nkhosa ndi Mbuzi.
Ma tapeworms
Ng'ombe, Mbuzi ndi Mbawala: Moniezia Species Thysanosoma (Fringed Tape worms)
Agalu: Dipylidium Caninum, Taenia Pisiformis T. hydatigena ndi T. taeniaeformis.
Mahatchi: Matenda a Anoplocephalid
Nkhuku: Raillietina ndi Davainea
Amphistomiasis: (Immature Paramphistomes)
Mu ng'ombe ndi Nkhosa, Rumen flukes (Paramphistomum mitundu) ndizofala kwambiri.Ngakhale kuti zingwe zazikulu zomwe zimamangiriridwa ku khoma la rumen sizingakhale zofunikira, zachinyamata zimakhala zowononga kwambiri komanso zimafa pamene zikusamukira ku khoma la duodenal.
Nyama zomwe zikuwonetsa zizindikiro za anorexia kwambiri, kuchuluka kwa madzi, komanso kutsekula m'mimba kwamadzi ziyenera kuganiziridwa kuti ndi amphistomiasis ndipo nthawi yomweyo kuthandizidwa ndi Niclosamide Bolus kuteteza kufa ndi kutayika kwa kupanga popeza Niclosamide Bolus imakhala yothandiza kwambiri nthawi zonse motsutsana ndi matenda osakhwima.
Kupanga
Bolus iliyonse yosaphimbidwa ili ndi:
Nicolosamide IP 1.0 gm
Ulamuliro ndi mlingo
Nicolosamide Bolus mu chakudya kapena motere.
Kulimbana ndi Tapeworms
Ng'ombe, Nkhosa ndi Mahatchi: 1 gm bolus kwa 20 kg kulemera kwa thupi
Agalu ndi Amphaka: 1 gm bolus kwa 10 kg kulemera kwa thupi
Nkhuku: 1 gm bolus kwa mbalame zazikulu zisanu
(Pafupifupi 175 mg pa kg kulemera kwa thupi)
Kulimbana ndi Amphistomes
Ng'ombe ndi Nkhosa:Mlingo wapamwamba kwambiri pamlingo wa 1.0 gm bolus / 10 kg kulemera kwa thupi.
Chitetezo:Niclosamide bolus ili ndi malire ambiri achitetezo.Kuchulukitsa kwa Niclosamide mpaka maulendo 40 pankhosa ndi ng'ombe kwapezeka kuti sikuli ndi poizoni.Kwa Agalu ndi amphaka, mlingo wovomerezeka kawiri kawiri umayambitsa mavuto aliwonse kupatula kufewa kwa ndowe.Niclosamide bolus itha kugwiritsidwa ntchito mosatekeseka mbali zonse za pakati komanso kwa anthu opuwala popanda zotsatirapo zoyipa.
