Niclosamide Bolus 1250 mg
Niclosamide Bolus imaletsa phosphorylation mu mitochondria ya cestodes. Mu vitro ndi mu vivo, zigawo za scolex ndi proximal zimafa zikakhudzana ndi mankhwala. Scolex yomasuka imatha kugayidwa m'matumbo; motero, zingakhale zosatheka kuzindikira scolex mu ndowe. Niclosamide Bolus imagwira ntchito yopha tizilombo toyambitsa matenda ndipo imachotsa osati zigawo zokha komanso scolex.
Ntchito ya Niclosamide Bolus motsutsana ndi nyongolotsi ikuwoneka kuti ikuchitika chifukwa cha kuletsa kwa phosphorylation ya mitochondrial oxidative; kupanga kwa ATP komwe sikungayendetsedwe kumakhudzidwanso.
Ntchito ya cestocidal ya Niclosamide Bolus imachitika chifukwa cha kuletsa kuyamwa kwa shuga ndi mphutsi za m'mimba komanso chifukwa cha kusakanikirana kwa njira ya oxidative phosphorylation mu mitochondria ya cestodes. Lactic acid yomwe imasonkhanitsidwa chifukwa cha kutsekeka kwa kayendedwe ka Krebs imapha mphutsi.
Zizindikiro
Niclosamide Bolus imapezeka m'matenda a ziweto, nkhuku, agalu ndi amphaka komanso m'matenda a paramphistomiasis (Amphistomiasis) a Ng'ombe, Nkhosa ndi Mbuzi.
Njoka zam'mimba
Ng'ombe, Nkhosa Mbuzi ndi Nswala: Mtundu wa Moniezia Thysanosoma (Fringed Tape worms)
Agalu: Dipylidium Caninum, Taenia Pisiformis T. hydatigena ndi T. taeniaeformis.
MahatchiMatenda a Anoplocephalid
Nkhuku: Raillietina ndi Davainea
Amphistomiasis: (Ma Paramphistomes Osakhwima)
Mu ng'ombe ndi nkhosa, ma Rumen fluke (mtundu wa Paramphistomum) ndi ofala kwambiri. Ngakhale kuti ma Rumen fluke akuluakulu omwe ali pakhoma la chimbudzi sangakhale ofunika kwenikweni, omwe sanakhwime amakhala ndi matenda oopsa kwambiri omwe amachititsa kuwonongeka kwakukulu komanso kufa akamasamukira ku khoma la duodenum.
Ziweto zomwe zikuwonetsa zizindikiro za anorexia yoopsa, kumwa madzi ambiri, komanso kutsegula m'mimba kochokera m'madzi ziyenera kuganiziridwa kuti zili ndi amphistomiasis ndipo nthawi yomweyo zilandire chithandizo ndi Niclosamide Bolus kuti zisafe komanso kutayika kwa zokolola chifukwa Niclosamide Bolus nthawi zonse imapereka mphamvu zambiri polimbana ndi tizilombo toyambitsa matenda.
Kapangidwe kake
Bolus iliyonse yosaphimbidwa ili ndi:
Niclosamide IP 1.0 gm
Kupereka ndi mlingo
Niclosamide Bolus mu chakudya kapena monga choncho.
Kulimbana ndi mphutsi za m'mimba
Ng'ombe, Nkhosa ndi Mahatchi: 1 gm bolus pa kulemera kwa thupi la 20 kg
Agalu ndi Amphaka: 1 gm bolus ya kulemera kwa thupi la 10 kg
Nkhuku: 1 gm bolus ya mbalame 5 zazikulu
(Pafupifupi 175 mg pa kg yolemera thupi)
Kutsutsana ndi Amphistomes
Ng'ombe ndi Nkhosa:Mlingo wokwera pamlingo wa 1.0 gm bolus / 10 kg yolemera thupi.
Chitetezo:Niclosamide bolus ili ndi chitetezo chachikulu. Kumwa Niclosamide mopitirira muyeso mpaka nthawi 40 mwa nkhosa ndi ng'ombe kwapezeka kuti sikuli poizoni. Mwa agalu ndi amphaka, mlingo woyenera kawiri sumabweretsa mavuto kupatula kufewa kwa ndowe. Niclosamide bolus ingagwiritsidwe ntchito mosamala nthawi zonse za mimba komanso kwa anthu ofooka popanda zotsatirapo zoyipa.
